How to fold an epithelium
During our everyday life, many of our tissues are subjected to large deformations. LCN scientists have now uncovered how tissues can rapidly adapt their length in response to deformation. The research, published in Nature Materials, provides us with a better...
Rare immune cells drive gut repair, but can tip toward cancer or fibrosis in inflammatory bowel disease
LCN researchers at King’s College London have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if dysregulated. The breakthrough will have important implications for treating patients who...
Mechanical stability regulates the nuclear import rate of translocating proteins
The nuclear pore complex (NPC) is the primary transport gateway for biomolecules to enter and exit the cell nucleus. It has long been known that the passage of proteins through the NPC is highly size-selective, and it was recently shown that the nuclear import rate...