Our lab develops and applies cutting-edge super-resolution imaging approaches to uncover the principles of cellular signaling and molecular organization in health and disease. While we focus on T cell function and immune responses, our work has recently expanded into virology, using imaging as a quantitative lens into complex biological processes.
Our research is organized around several complementary themes:
Super-resolution and quantitative imaging: We design and implement single-molecule and DNA-PAINT techniques to map protein networks in cells with single-protein precision.
Multiplexed imaging and clustering analysis: We develop strategies to simultaneously visualize multiple molecular targets, enabling quantitative mapping of protein interactions and signaling pathways.
Whole-cell and dynamic imaging: We push the boundaries of volumetric and live-cell imaging, capturing dynamic processes across entire cells with high spatial and temporal resolution.
Advanced single-molecule techniques: We advance methods for lifetime imaging, force measurements, and other nanoscale readouts, linking molecular behavior to functional cellular outcomes.
By combining innovative microscopy with rigorous computational analysis, our lab delivers precise, quantitative insights into cellular signaling, molecular interactions, and nanoscale organization—bridging methodological innovation with applications in immunology, virology, and beyond.
