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Yuri Korchev | London Centre for Nanotechnology

Prof Yuri Korchev

tel: +44 (0)20 8383 3080
ext: 2362
fax: +44 (0)20 7594
office:

Medicine

Research interests:

The use of microscopy to study the dynamic properties of living cells
Biomedical applications of scanning ion conductance microscopy

Biography:

Prof Yuri Korchev gained a BSc in Biology & Physiology, a Diploma in University Teaching, and an MSc in Physiology, at the University of St Petersburg, and a PhD (biophysics of ion transport) at the Russian Academy of Sciences. From 1984, he held the post of Research Scientist at the Institute of Cytology, Russian Academy of Sciences, St Petersburg. In 1991 he joined St George's Hospital Medical School, London as a Wellcome Trust Research Fellow and then as a Post-Doctoral Research Fellow. In 1995 he moved to Charing Cross & Westminster Medical School as a Post-Doctoral Research Fellow, and in 1997 became a lecturer at Imperial College School of Medicine, Division of Medicine, Hammersmith Campus. In 2003, Yuri was appointed as Reader and in 2005 as Professor of Biophysics. He now heads the Nanomedicine laboratory at Imperial College London.Yuri is non-executive Chief Scientist of Ionoscope limited.

Research: 

Prof Yuri Korchev research interests include SICM for reliable imaging of living cells, alone and in combination with fluorescence microscopy and patch clamp for functional imaging, and the use of SCIM for scanning near field optical microscopy. In cellular biology, he researches the role of mechano-sensitivity in cells and in action of hormones in regulation of ion channels; the mapping of the distribution of single functional channels in living cells. In the field of biosensors, he is interested in the use of nanopipettes as biosensors.

Recent Publications
Journals

  • Dutta AK; Korchev YE; Shevchuk AI; Hayashi S; Okada Y; Sabirov RZ. (01 Mar 2008). Spatial distribution of maxi-anion channel on cardiomyocytes detected by smart-patch technique. Biophys J. 94:1646-1655. Publisher weblink DOI.
  • Bruckbauer A; James P; Zhou D; Yoon JW; Excell D; Korchev Y; Jones R; Klenerman D. (01 Nov 2007). Nanopipette delivery of individual molecules to cellular compartments for single-molecule fluorescence tracking. Biophys J. 93:3120-3131. Publisher weblink DOI.
  • Zhang Y; Sanchez D; Gorelik J; Klenerman D; Lab M; Edwards C; Korchev Y. (Jun 2007). Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia. Am J Physiol Renal Physiol. 292:F1734-F1740. Publisher weblink DOI.
  • Sánchez D; Anand U; Gorelik J; Benham CD; Bountra C; Lab M; Klenerman D; Birch R; Anand P; Korchev Y. (15 Jan 2007). Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy. J Neurosci Methods. 159:26-34. Publisher weblink DOI.
  • Korchev Y; Sanchez D; Anand P; Gorelik J; Zhang YJ; Shevchuk A; Vodyanoy I; Lab M; Klenerman D. (Jan 2007). "Non-contact" mechanical characterization and stimulation of cells using scanning ion conductance microscopy. BIOPHYS J. 33A-33A.
  • Johnson N; Li C; Ostanin V; Bruckbauer A; Korchev Y; Klenerman D. (Jan 2007). Improved scanning ion conductance microscopy (SICM) for live cell imaging. BIOPHYS J. 323A-323A.
  • Piper JD; Clarke RW; Korchev YE; Ying L; Klenerman D. (27 Dec 2006). A renewable nanosensor based on a glass nanopipette. J Am Chem Soc. 128:16462-16463. Publisher weblink DOI.
  • Gorelik J; Yang LQ; Zhang Y; Lab M; Korchev Y; Harding SE. (01 Dec 2006). A novel Z-groove index characterizing myocardial surface structure. Cardiovasc Res. 72:422-429. Publisher weblink DOI.
  • Korchev Y; Zhang Y; Gorelik J; Edwards CRW. (Oct 2006). Paracrine role of ATP in aldosterone action on epithelial cells and cardiomyocytes. HYPERTENSION. 48:764-764.
  • Yang LQ; Gorelik J; Korchev Y; Harding SE. (Jun 2006).Increase in beta(1)AR-Gi coupling after detubulation in rat ventricular myocytes. J MOL CELL CARDIOL. 40:923-924. DOI.
  • Klenerman D; Korchev Y. (Jun 2006).Potential biomedical applications of the scanned nanopipette. NANOMEDICINE-UK. 1:107-114. DOI.
  • Gorelik J; Patel P; Ng'andwe C; Vodyanoy I; Diakonov I; Lab M; Korchev Y; Williamson C. (May 2006). Genes encoding bile acid, phospholipid and anion transporters are expressed in a human fetal cardiomyocyte culture. BJOG. 113:552-558. Publisher weblink DOI.
  • Gorelik J; Ali NN; Shevchuk AI; Lab M; Williamson C; Harding SE; Korchev YE. (Apr 2006). Functional characterization of embryonic stem cell-derived cardiomyocytes using scanning ion conductance microscopy. Tissue Eng. 12:657-664. Publisher weblink DOI.
  • Shevchuk AI; Frolenkov GI; Sánchez D; James PS; Freedman N; Lab MJ; Jones R; Klenerman D; Korchev YE. (27 Mar 2006). Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy. Angew Chem Int Ed Engl. 45:2212-2216. Publisher weblink DOI.
  • Rodolfa KT; Bruckbauer A; Zhou D; Schevchuk AI; Korchev YE; Klenerman D. (Feb 2006). Nanoscale pipetting for controlled chemistry in small arrayed water droplets using a double-barrel pipet. Nano Lett. 6:252-257. Publisher weblink DOI.
  • Rodolfa KT; Bruckbauer A; Zhou D; Korchev YE; Klenerman D. (28 Oct 2005). Two-component graded deposition of biomolecules with a double-barreled nanopipette. Angew Chem Int Ed Engl. 44:6854-6859. Publisher weblink DOI.
  • Gorelik J; Zhang Y; Sánchez D; Shevchuk A; Frolenkov G; Lab M; Klenerman D; Edwards C; Korchev Y. (18 Oct 2005). Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited. Proc Natl Acad Sci U S A. 102:15000-15005. Publisher weblink DOI.
  • Zhang Y; Gorelik J; Sanchez D; Shevchuk A; Lab M; Vodyanoy I; Klenerman D; Edwards C; Korchev Y. (Sep 2005). Scanning ion conductance microscopy reveals how a functional renal epithelial monolayer maintains its integrity. Kidney Int. 68:1071-1077. Publisher weblink DOI.
  • Ying L; Bruckbauer A; Zhou D; Gorelik J; Shevchuk A; Lab M; Korchev Y; Klenerman D. (07 Aug 2005). The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules. Phys Chem Chem Phys. 7:2859-2866. Publisher weblink DOI.
  • Brette F; Korchev Y; Orchard CH. (Jun 2005). Functional localization of cardiac and neuronal sodium currents in rat ventricular myocytes. J MOL CELL CARDIOL. 38:1006-1007.
  • Duclohier HPM; Gorelik J; Yang LQ; Harding SE; Korchev YE. (Jan 2005). Distribution of sodium channels in ventricular heart cells. BIOPHYS J. 88:378A-378A.
  • Gorelik JV; Benton DCH; Monaghan A; Lab MJ; Vodyanoy I; Klenerman D; Moss GWJ; Korchev YE. (Jan 2005). Studying of neuronal synapses by scanning ion conductance microscopy. BIOPHYS J. 88:305A-305A.
  • Gu Y; Kirkman-Brown JC; Korchev Y; Barratt CL; Publicover SJ. (15 Oct 2004). Multi-state, 4-aminopyridine-sensitive ion channels in human spermatozoa. Dev Biol. 274:308-317. Publisher weblink DOI.
  • Gorelik J; Shevchuk A; de Swiet M; Lab M; Korchev Y; Williamson C. (Aug 2004). Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes. BJOG. 111:867-870. Publisher weblink DOI.
  • Bruckbauer A; Zhou D; Kang DJ; Korchev YE; Abell C; Klenerman D. (02 Jun 2004).An addressable antibody nanoarray produced on a nanostructured surface. J Am Chem Soc. 126:6508-6509. Publisher weblink DOI.
  • Gorelik J; Zhang Y; Shevchuk AI; Frolenkov GI; Sánchez D; Lab MJ; Vodyanoy I; Edwards CR; Klenerman D; Korchev YE. (31 Mar 2004). The use of scanning ion conductance microscopy to image A6 cells. Mol Cell Endocrinol. 217:101-108. Publisher weblink DOI.
  • Ying L; White SS; Bruckbauer A; Meadows L; Korchev YE; Klenerman D. (Feb 2004). Frequency and voltage dependence of the dielectrophoretic trapping of short lengths of DNA and dCTP in a nanopipette. Biophys J. 86:1018-1027. Publisher weblink.
  • Darszon A; Wood CD; Beltrán C; Sánchez D; Rodríguez E; Gorelik J; Korchev YE; Nishigaki T. (2004). Measuring ion fluxes in sperm. Methods Cell Biol. 74:545-576. Publisher weblink.