Matthew Fuchter

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Dr Matthew J Fuchter

Dr Matthew Fuchter

Senior Lecturer
Telephone Number: 
020 7594 5815
Office/Location: 
Chemistry
Biography
Biography: 

Matt Fuchter is a Lecturer in Synthetic and Medicinal Chemistry. He carried out his Ph.D. studies (2002-2005) and nine-months postdoctoral work with Professor A.G.M. Barrett at IC on porphyrazine chemistry and their biomedical applications, particularly as optical imaging and photodynamic therapeutic agents. Despite his recent lectureship appointment (2008), he has already attracted significant research funding: More than £750K as a Principle Investigator (PI), and a further £1.5M as Co-Investigator (CI). His burgeoning reputation has been enhanced by appointments as a RCUK Fellow (2007) and Distinguished Visiting Fellow (Univ. of Melbourne), and invitations to lecture at several prestigious international symposia. He is the Senior Investigator in Cancer Medicinal Chemistry within CD3. The Fuchter Group is focused on synthetic organic and medicinal chemistry, particularly epigenetic anti-cancer therapeutics. For more information see here.

Dr Matthew Fuchter obtained his first class honours degree (MSci) from the University of Bristol in 2002, where he was awarded the Richard N. Dixon prize as well as an undergraduate scholarship and several faculty commendations.

In January 2006 he completed his PhD research entitled “Synthetic Studies on Porphyrazines: Biological Applications and New Preparative Methods” under the supervision of Professor A. G. M. Barrett, FRS FMedSci at Imperial College London. Within the group of Professor Barrett, he was promoted to the position of Group Leader, which involved numerous supervisory and organisational responsibilities.
Following a short spell as a Research Associate at Imperial College, Dr Fuchter was appointed as a CSIRO Research Fellow at the Commonwealth Scientific and Industrial Research Organisation, Australia as well as a visiting fellow at the University of Melbourne, where he worked with Professor A. B Holmes, FRS. From August 2007 he was the RCUK Academic Fellow in Cancer Medicinal Chemistry at the School of Pharmacy, University of London, and in July 2008 he was appointed as a Lecturer in Synthetic and Medicinal Chemistry at Imperial College London. He was promoted to Senior Lecturer in July 2012.

Selected Publications

Journals

Judge D, Haycock P, Richardson R, et al., 2013, ortho-Substituted 1,8-Diarylnaphthalenes: Conformational Thermodynamics and Kinetics, Synlett, ISSN:0936-5214

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Kaliszczak M, Patel H, Kroll SH, et al., 2013, Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance., Br J Cancer, 0007-0920

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Cherblanc FL, Lo YP, Herrebout W, et al., 2013, Mechanistic and chiroptical studies on the desulfurization of epidithiodioxopiperazines reveal universal retention of configuration at the bridgehead carbon atoms., J Org Chem

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Cherblanc FL, Chapman K, Reid J, et al., 2013, On the histone lysine methyltransferase activity of fungal metabolite chaetocin., J Med Chem

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Yang Y, Correa da Costa R, Fuchter MJ, et al., 2013, Circularly polarized light detection by a chiralorganic semiconductor transistor, Nature Photonics, Vol:7, 1749-4885, Pages:634-638

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Yang Y, da Costa RC, Smilgies DM, et al., 2013, Induction of Circularly Polarized Electroluminescence from an Achiral Light-Emitting Polymer via a Chiral Small-Molecule Dopant., Adv Mater, Vol:25, 0935-9648, Pages:-

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Weimar M, Correa da Costa R, Lee F-H, et al., 2013, A Scalable and Expedient Route to 1‐Aza[6]helicene Derivatives and Its Subsequent Application to a Chiral-Relay Asymmetric Strategy, Organic Letters, Vol:15, 1523-7060, Pages:1706-1709

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Fuchter MJ, Judge DK, Weimar M, et al., 2013, Stoichiometric C-H arylation of tricarbonyl(arene)chromium complexes bearing pyridine directing groups., Dalton Trans, Vol:42, 1477-9226, Pages:5615-5618

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Cherblanc FL, Davidson RW, Di Fruscia P, et al., 2013, Perspectives on natural product epigenetic modulators in chemical biology and medicine., Nat Prod Rep, Vol:30, 0265-0568, Pages:605-624

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Cherblanc F, Chapman KL, Brown R, et al., 2013, Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases, Nature Chemical Biology, Vol:9, 1552-4450, Pages:136-137

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Baud MGJ, Leiser T, Petrucci V, et al., 2013, Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors, Beilstein Journal of Organic Chemistry, Vol:9, 1860-5397, Pages:81-88

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Baud MG, Haus P, Leiser T, et al., 2013, Highly ligand efficient and selective N-2-(Thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A., ChemMedChem, Vol:8, 1860-7179, Pages:149-156

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Weimar M, Fuchter MJ, 2013, Synthesis of sterically encumbered C10-arylated benzo[h]quinolines using ortho-substituted aryl boronic acids., Org Biomol Chem, Vol:11, 1477-0520, Pages:31-34

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Awards and honours: 
  • Faculty of Natural Sciences Award for Excellence in Teaching, Imperial College, 2013
  • College President and Rector’s award for Excellence in Teaching 2013, Imperial College, 2013
Memberships : 

Member, British Association of Cancer Research

  • Member, Royal Society of Chemistry
  • Member, American Chemical Society