Dr Andrew Thorley is a Lecturer in the Lung Cell Biology Group at the National Heart and Lung Institute with a research focus on nanotechnology and pulmonary innate immunity. Dr Thorley also teaches on a number of undergraduate Medicine, Biomedical Science, and Engineering courses.
Dr Thorley graduated from the University of Bath in 2000 with a Masters in Pharmacology. During his undergraduate study, he spent a year working for Bayer plc investigating the role of matrix metalloproteinases in pulmonary alveolar macrophage-mediated inflammation and tissue remodelling. He subsequently joined Professor Tetley’s Lung Cell Biology group at the National Heart and Lung Institute to undertake a PhD investigating the role of alveolar macrophages, dendritic cells, and respiratory epithelial cells in lung inflammation, with a particular focus on Toll-like receptor activation and bacterial infection.
Dr Thorley has continued his research at Imperial College by developing his work on Toll-like receptors, investigating the effects of cigarette smoke and Toll-like receptor activation on the inflammatory response of the alveolar macrophage and epithelium. More recently, his research has expanded to study the interaction of engineered nanoparticles with cells of the peripheral lung. This programme of research includes how engineered nanoparticles may modfy the host response to microbial ligands, how physicochemical properties of nanoparticles affect their interaction with, and uptake by, pulmonary cells and the development of antibody-tagged metal nanoparticles as novel vectors for pulmonary drug delivery.
In addition to his academic work, Dr Thorley is a committee member of the British Association for Lung Research and also sits on the Public Engagement committee for the Society of Biology and the Nanotechnology committee for the British Standards Institute. He is also a member of the MRC-PHE Centre for Environment and Health and sits on their Training Programme Committee. Furthermore, he is a reviewer for a number of international journals including: Journal of Immunology, Chest, Thorax, Respiratory Research, International Journal of COPD, Particle and Fibre Toxicology, Nanotechnology and Nanobiotechnology.
Tetley TD, Thorley AJ, 2013, Health effects, Biochemist, Vol:35, ISSN:0954-982X, Pages:14-20
Solomon A, Smyth E, Mitha N, et al., 2013, Induction of platelet aggregation after a direct physical interaction with diesel exhaust particles., J Thromb Haemost, Vol:11, 1538-7933, Pages:325-334
Chen S, Goode AE, Sweeney S, et al., 2013, Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism., Nanoscale, Vol:5, 2040-3364, Pages:-
Thorley AJ, Tetley TD, 2013, New Perspectives in Nanomedicine., Pharmacol Ther, Vol:140, 0163-7258, Pages:-
Ruenraroengsak P, Novak P, Berhanu D, et al., 2012, Respiratory epithelial cytotoxicity and membrane damage (holes) caused by amine-modified nanoparticles., Nanotoxicology, Vol:6, 1743-5390, Pages:94-108